Novel Trophy Study Is First To Evaluate Effects Of Pharmacological Intervention In Patients With Prehypertension

Results of the TROPHY analysis (Trial Of Preventing Hypertension) be presented today within the late-breaking clinical examination prior arrangement at the American College of Cardiology's 55th Annual Scientific Session. "The TROPHY study be groundbreaking because it's the first study to solicit into the probable to alteration the inbred long-ago of hypertension through hasty pharmacological negotiation in patients diagnose beside prehypertension," said principal investigator Stevo Julius, MD, Professor of Internal Medicine and Physiology, University of Michigan. For the earliest study expiration spine of perfection of hypertension, here be a 15.6% qualified menace markdown in the conglomerate treat with ATACAND® (candesartan cilexetil) compare with the group treated with placebo (53.2% vs 63.0% p<.007). According to Dr Julius, "The TROPHY study was designed to impart data of theory all for the possibility of using a pharmacologic intervention to affect the natural history of hypertension." Extensive clinical go through biased the efficacy, sanctuary and tolerability of ATACAND in hypertension made it an help yourself to resolution by handiness of means of the pharmacologic agent for reconnaissance in TROPHY. ATACAND is stand for for the cure of hypertension. ATACAND is not indicated to preclude the development of hypertension or for the treatment of prehypertension. In mixing, ATACAND® (candesartan cilexetil) is indicated for the treatment of heart sink (NYHA standing II-IV) in patients with left-ventricular systolic dysfunction (ejection paragraph <=40%) to willowy down cardiovascular release and to reduce heart failure hospitalizations. ATACAND also have an added effect by the side of these outcome when nearly up to date with an ACE inhibitor.

Hypertension is defined as a blood anxiety of 140/90 mm Hg or sophisticated and is one of the maximum rife cardiovascular disease in the United States, affecting an ballpark 65 million those or going on for one in three adults. Most of the mortality and morbidity from hypertension crop up among subject with time 1 (mild) hypertension. The rationale transport up the flipside TROPHY is that if it were impending to prevent the transition from prehypertension to stage 1 hypertension, there could be a gainful blessing on population enthusiasm.

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