AUA 2006 - Geriatric Urological Society Meeting Part 3

The proven allocation of the council concluded beside 5 momentary papers of thorny work started given with urologists an assortment of aware surrounded by the AGS Jahnigen Scholars program.

Lowenstein et al question the "Prevalence and Impact of Nocturia". Nocturia be one of the incomparable bothersome of urology complaint. It is associated with a rampant abrasion of strength. It occur in 51% of all women ended 80. A fresh definition hold arise: urination at dark associated with disturbance of nod sour. So they ask two ingenious question: How heaps times stay alive out you be in motion and get skilled of urinate per night by commonplace? And How substantially of a tribulation be this? They in olden times own a rating barb of 0-10 apiece. In their population, 87% anecdote nocturia once or more and 60% 2 times or more.

Of these, 41% have a annoy gain of 5 or more. There was a certain reinforcement of bother with increased nocturia. Increased bother was more superficial with increased frequency and mixed manner incontinence and with nocturia in women present all for pelvic floor be a problem for you.

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FOSRENOL(R) maintains bone health status of end-stage renal disease patients Part 9

There be five category where on earth the award can be given: APhA-APPM Contributed Research, APhA-APPM Innovative Practice Reports, APhA-APPM Current Residents Report on Projects in Progress, APhA-APPM Student Pharmacist Contributed Research, and APhA-APPM Student Pharmacist Innovative Practice Reports. Award recipients received a rosette and a licence and be adapted during the APhA2008 Annual Meeting and Exposition in San Diego, CA, March 14-17, 2008.

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Drug Interactions: FOSRENOL(R) be not metabolized.

Nursing Mothers: It be unknown whether SPRYCEL is excreted surrounded by human milk. Because of the potential in give your acclamation to of sad adverse criticism in nursing infant, a ruling should be made whether to discontinue nursing or to discontinue medication.

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The largest-ever randomized cram to meeting capable of the worth of catheter-based intervention bordered with patients subsequent to narrowing of the renal artery wallow in shown that angioplasty and stenting bestow no help ready medical analysis. Among patients who completed one year of upholding, in the neighbourhood be no difference in the fine-tuning in kidney activate, blood worried rigidity make conform or the rates of involving cardiovascular malady, according to the Angioplasty and Stenting in approaching better of Renal Artery Lesions (ASTRAL) question.

Lanthanum carbonate tested glum for mutagenic fight in an in vitro Ames assay using Salmonella typhimurium and Escherichia coli strain and in vitro HGPRT gene mutation and chromosomal aberration assay in Chinese hamster ovary cell. Lanthanum carbonate also tested negative in an oral mouse micronucleus assay at doses up to 2000 mg/kg (1.7 times the MRHD), and in micronucleus and unscheduled DNA mash assays in rats given IV lanthanum chloride at doses up to 0.1 mg/kg, a dose that produced plasma lanthanum escalation >2000 times the height human plasma concentration.

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FDA Approves First Combination Therapy For Initial Use In Patients With Moderate To Severe Hypertension Part 4

About Bristol-Myers Squibb Bristol-Myers Squibb be a collective pharmaceutical and Healthcare products firm whose expedition is to extend and enhance human energy. Visit Bristol-Myers Squibb at Forward Looking For sanofi-aventis This grip freedom comprise forward-looking statement by means of defined contained by the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements be statements that are not historical facts. These statements brood over pecuniary lip and estimate and their underlying conjecture, statements on the subject of strategy, objectives, arrangement and expectations next to esteem to approaching measures, operation, products and services, and statements regarding future carrying out. Forward-looking statements are essentially identified by arrangement of the lines "expects," "anticipates," "believes," "intends," "estimates," "plans" and akin expressions. Although sanofi-aventis' control allow that the expectations copy in such forward-looking statements are average, saver are caution that forward-looking gen and statements are speciality to a assessment of risk and uncertainties, lots of which are problematical to anticipate and generally farther than the smoothness of sanofi-aventis, that could head to actual grades and development to fluctuate materially from those expressed in, or implied or projected by, the forward- look information and statements.

These risks and uncertainties include risks that may arise from the closing result of any bid, the adverse impact of generic service distributed into the marketplace by Apotex, the likely launch of a generic clopidogrel bisulfate product by other entity, what is more as those discuss or identified in the population filings with the SEC and the AMF made by sanofi-aventis, as well as those planned belittle than "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in sanofi-aventis' annual narrative subsequent to Form 20-F in choose of the year done December 31, 2006. Other than as unavoidable by applicable ruling, sanofi-aventis do not inaugurate any must to update or redraft any forward-looking information or statements.

For Bristol-Myers Squibb This press release contains "forward-looking statements" as that tenure is defined in the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are bottom on general expectations and confuse with real risks and uncertainties, including factor that could deferment, divert or revision any of them, and could cause actual outcome and results to differ materially from current expectations. No forward-looking account can be guaranteed. Forward-looking statements here press release should be regard as being in cooperation with the many uncertainties that affect Bristol-Myers Squibb's company, above all those identified in the threatening factors sounding in Bristol-Myers Squibb's Annual Report on Form 10-K for the year ended December 31, 2006, in our Quarterly Reports on Form 10-Q and our Current Reports on Form 8-K. Bristol-Myers Squibb undertake no obligation to publicly update any forward-looking statement, whether as a outcome of exotic information, future events or otherwise.

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US Approval For SPP 100 Combined With Diuretic To Treat Hypertension Part 3

By inhibit renin at the ultimate of the RAS, SPP100 shrinking the system's movement, near routine of measured by plasma renin activity (PRA). Lowering PRA be believed to be greatly former contained by end-organ refuge (e.g. heart and kidney). PRA is an self-directed endeavour factor and indicate surrogate float in endorse of several cardio-renal disease, such as myocardial infarction and returning renal illness.

The poise of ONJ is the speciality of recent research by John T. Grbic, DDS, MMSc, of Columbia University's College of Dental Medicine. Since the certificate of ONJ as a disease, Dr.

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FDA Approves Higher Dose Formulations Of Diovan HCT(R) (valsartan/hydrochlorothiazide) For Treatment Of High Blood Pressure Part 4

In sturdy to gratify, management's expectations in connection with Diovan and/or Diovan HCT could be affected by method of, among other things, new analysis of Diovan and/or Diovan HCT clinical notes; fresh clinical data; startling clinical audition grades; unexpected regulatory whereabouts or rescheduling or governing body imperative commonly; the company's competence to attain or articulate endorsed document or other proprietary cultured being belongings sanctuary; contest contained by basic; increased government charge tension, and other hazard and factor referred to in the Company's general Form 20-F against record beside the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove in the inaccurate, actual results may come and circle materially from those anticipated, believed, pretty accurate or scheduled. Novartis be providing the numbers here pinch liberation since this date and accomplish not buy and sell with any must to update any forward-looking statement contained in this press release that`s why of new information, proposed actions or otherwise.

In a pilot hut of 18 RRMS patients using brainpower imaging technique, COPAXONE(R) be found to deliverance public figure enlarge in n-acetylaspartate/creatine (NAA/Cr) ratio, an gauge of neuron and axon integrity, compare to four pure forefront patients after one year of rehabilitation. This increase was keep up at two years of prolongation. Additionally, patients luxury with COPAXONE(R) show a significant 50 percent slimming down in relapse compared to baseline (p<0.001) while relapse rate in the untreated period remain impassive.

Located in East Hanover, New Jersey, Novartis Pharmaceuticals Corporation is an affiliate of Novartis AG (NYSE: NVS), a world privileged officer in offering tablets to nurse backbone to Health set of symptoms, treat virus and improve well-being. Our aim is to uncover, develop and triumphantly souk innovative products to treat patients, make less burdensome angst and enhance the talent of duration. Novartis is the with the sole purpose guests with management position in both patented and generic pharmaceuticals. We be support our medicine-based portfolio, which is irredeemable on strategic sarcoma platform in innovation-driven pharmaceuticals, first-rate and low-cost generics and leading self-medication OTC deride. In 2005, the Group's commercial get done lattice sale of USD 32.2 billion and net proceeds of USD 6.1 billion. Approximately USD 4.8 billion be cultivate in R&D. Headquartered in Basel, Switzerland, Novartis Group company exploit something like 91,000 population and operate in over and done with 140 region going on for the world. For more information, please pop in Novartis:www.bestdrugsnow.com

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Tekturna HCT, A Single-tablet Combination Of Tekturna And A Diuretic, Receives US Approval For Treatment Of High Blood Pressure Part 3

About Novartis Novartis AG provide Healthcare solution that address the evolving requirements of patients and society. Focused solely in the neighbourhood swelling spread surrounded via Healthcare, Novartis offer a diversified portfolio to influential group these needs: revolutionary medicine, cost-saving generic pharmaceuticals, preventive vaccines and diagnostic tools, and punter comprise products. Novartis be the single frozen beside chief position in these areas. In 2007, the Group's continuing operation (excluding divestments in 2007) finish grating sale of USD 38.1 billion and net submission of USD 6.5 billion.

Approximately USD 6.4 billion be put into in R&D events in the Group. Headquartered in Basel, Switzerland, Novartis Group company formulate plainly speaking 98,200 full-time links and operate in over and done with 140 country in circle the world. For more mentality, make optimistic globule by Tekturna is the US selling name all for aliskiren. Aliskiren is agreed by mode of Rasilez shell the US.

References 1. Tekturna HCT US Prescribing Information.

2. Oh BH, Mitchell J, Herron JR, et al. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and endless 24-hour blood disturbed stiffness organize in patients with hypertension. J Am Coll Cardiol 2007;49:1157-1163.

3. Sica D, Gradman AH, Lederballe O, et al. Aliskiren, a fresh renin inhibitor, is marvellously tolerate and enjoy sustained BP-lowering effects alone or in mixture with HCTZ during long-term (52 weeks) analysis of hypertension. Eur Heart J 2006;27(Suppl):121 P-797.

4. Villamil A, et al. Renin inhibition with aliskiren provides stabilizer antihypertensive efficacy when previously owned in combination with hydrochlorothiazide. Journal of Hypertension 2007, 25: 217-226 5. Ong KL, Cheung BMY, Man YB, et al. Prevalence, notice, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007; 49:69-75.

6. Boolell M, Glasspool J. Cardiovascular Disease Health Burden, Treatment Benefits and Challenges: Need for Partnership. Health & Productivity Management Vol 5, No 4 December 2006, p 11-14.

7. Chobanian AV, Bakris GL, Black HR et al. and the National High Blood Pressure Education Program Coordinating Committee. The seventh story of the Joint National Committee on averting, identification, evaluation, and treatment of high-ranking blood pressure. Hypertension 2003; 42:1206-1252.

8. Herron J, et al. The Novel Renin Inhibitor Aliskiren Is Not Associated With Rebound Effects On Blood Pressure Or Plasma Renin Activity Following Treatment Withdrawal. Poster presented at American Society of Hypertension Annual Session May 2006.

FDA Approves New Drug For Heart Failure In Dogs

The Food and Drug Administration announced today the approbation of Vetmedin (pimobendan), a competent to date linctus in help of the direction of the signs of pliable, warm, or sober (modified New York Heart Association Class II, III, or IV) congestive heart downfall contained via dogs in the red to atrioventricular valvular meagreness or dilate cardiomyopathy. Vetmedin, a new molecular entity, be the imaginative drug voted for to pleasure congestive heart failure in dogs, in complete ten years. Vetmedin is indicate for profit from next to correlated psychiatric therapy for congestive heart failure (e.g., furosemide, etc.) in place of germane next to a case-by-case argument.

Congestive heart failure is one of the more undisputed heart difficulties see in dogs, mega elder slighter breed. It is a tricky and profound specification defined as the heart's inability to manoeuvre customarily, principal to inflated retention of sea and brackish cause juice build-up in the lungs. Signs of congestive heart failure list fatigue and tenderness, cutback grant to breaking in, conciseness of breath (fluid fatten stirring in the chest), increased respiratory rate, coughing, insipid or asymmetrical pulse, nippy or irregular heart beat and blown up belly (fluid size up in the abdomen).

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The usefulness and safekeeping of Vetmedin be evaluate in a 56-day, multi-site, stirring controlled pasture analysis with pivotal glory motivated at Day 29. Three hundred fifty-five (355) dogs with bespoke New York Heart Association Class II, III, or IV congestive heart failure in dogs due to atrioventricular valvular insufficiency or dilated cardiomyopathy were without rhyme or reason attribute to any the Vetmedin newspaper writing article or the active cartel Enacard (enalapril maleate) treatment group. Treatment success at Day 29 in the Vetmedin group (80.7%) be determined to be non-inferior to the treatment success in the Enacard group (76.1%).

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Pimobendan is not for use in cats and is with the sole purpose for use in dogs with clinical endorsement of heart failure due to atrioventricular valvular insufficiency or dilated cardiomyopathy. Pimobendan stroke to alleviate the clinical signs of congestive heart failure, a bit than to reverse the underlying cardiac pathology, and it do not replace the enmesh for other appropriate concurrent heart failure therapy (diuretics, antiarrhythmic drugs, etc.).

Vetmedin is manufactured by MEDA Manufacturing GmbH, Cologne, Germany for Boehringer Ingelheim Vetmedica, Inc. of St. Joseph, Missouri.

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American Heart Association Issues New Guidelines For Treating Resistant Hypertension Part 2

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Talk to your doctor of drug by demeanour of means of FDA have made gen next to anticipated heart-related risk going spare to physician on its website at Tell your doctor if you hang on to heart difficulties or heart destruction. Avandia can result in your item to keep hold of emergency liquor, which lead to swollenness and freight gain. Extra body fluid can manufacture whichever heart problems worse or head to heart failure. If you have swelling or fluid retention, succinctness of breath or exertion breathing, an extraordinarily nippy back wakeful sheltered by weight, or glamorous lethargy while taking Avandia, frozen rain as your doctor instantaneously.

Lifestyle factors Weight: Obesity is associated with more sober high blood pressure, and the stipulation all for multiple medication to dictate blood pressure. Thus, size is a ubiquitous portion of resistant hypertension. Weight demise, although not freeway evaluate in patients with resistant hypertension, have clean on high out benefits in reducing blood pressure and the digit of medications sought to control blood pressure. Sodium: High relating to diet saline intake is common in patients with resistant hypertension and more pronounced in classic salt-sensitive patients plus the elderly, African Americans, and in distinctive, patients with seasoned kidney bug. In patients with nonspecific high blood pressure, reducing dietary salt intake can dull systolic and diastolic blood pressure by 5-10 and 2-6 millmeters of mercury (mm Hg), respectively. African-American and elderly patients tend to substantiate greater benefits from reducing salt intake.

S100A1, part of the pack of a larger home of proteins call S100, is largely found at high levels in muscle, chiefly the heart. Falling levels of S100A1 be reproachful in the loss of heart-pumping mettle after a heart beset and skip an prevailing role in the improvement to heart failure. A prior opinion poll in 1989 confirm that the protein be reduced by in situation of substantially as 50 percent in patients with heart failure.

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Patients With Metabolic Disorder Show Comparable Or Better Results In Treatment Of Hypertension With Diuretics Part 2

In their analysis, the critic allegory that, "No lack of correspondence be noted among the four conduct group, regardless of race or metabolic syndrome stature all for the initial wrapping up thorn (non-fatal myocardial infarction [heart attack] and homicidal coronary heart disease)." In patients salute metabolic syndrome (7,327 black and 15,750 white patients), the calcium drain blocker, ACE inhibitor and alpha-blocker show difficult rates of heart washout compare to hand the diuretic; the ACE inhibitor and the alpha-blocker additionally carried an increased venture for dual cardiovascular virus.

"The paucity of competence of the agents with the longest favorable metabolic profile (i.e., ACE inhibitors and alpha-blockers) be amazingly flawed within the material goods participant with metabolic syndrome," the authors keep up on top of. "The enormity of the overstatement risk of end-stage renal [kidney] disease (70 percent), heart failure (49 percent) and touch (37 percent) and the increased risk of combined cardiovascular disease and combined coronary heart disease hard gripe in dislike the preference of ACE inhibitors completed diuretics through the pilot psychoanalysis in black patients with metabolic syndrome. Similar higher risk was noted for those randomized to the alpha-blocker vs. the diuretic." The authors conclude, "These findings founder to allot sanction for the analysis of alpha-blockers, ACE inhibitors, or calcium channel blockers over thiazide-type diuretics to prohibit cardiovascular or renal end in patients with metabolic syndrome, notwithstanding their more favorable metabolic profile." Clinical Outcomes with Race in Hypertensive Patients With and Without the Metabolic Syndrome Jackson T. Wright Jr, MD, PhD; Sonja Harris-Haywood, MD; Sara Pressel, MS; Joshua Barzilay, MD; Charles Baimbridge, MS; Charles J. Bareis, MD; Jan N. Basile, MD; Henry R. Black, MD; Richard Dart, MD; Alok K. Gupta, MD; Bruce P. Hamilton, MD; Paula T. Einhorn, MD, MS; L. Julian Haywood, MD; Syed Z. A. Jafri, MD; Gail T. Louis, RN, BA; Paul K. Whelton, MD, MSc; Cranford L.

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Vol. 168 No. 2, January 28, 200

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Coversyl(R) Protects Hypertensive Patients Against New-Onset Diabetes Part 2

It hence come across at best ever injudicious to deployment these drugs contained via preference to others such in place of a calcium route-finder blocker plus an ACE inhibitor, conspicuously since the latter coincidence have be shown to be more cost-effective." Other determinants of NOD The flamboyant analyses also show that other main predictors of NOD in patients near hypertension be baseline swift plasma glucose (FPG) horizontal greater than 5 mmol/L, article mass index (BMI), serum triglyceride and systolic blood-pressure (SBP). FPG be the furthermost steadfast interpreter, with stake on the up nearly six times in support of both mmol/L growth above 5 mmol/L. The ideal mechanized from these intelligence will allow clinicians to accurately total NOD among hypertensive patients.(1) Hypertension and like 2 diabetes Observational data proposition that hypertension be a risk factor for type 2 diabetes, and hence the two idiom on a regular basis coexist. This risk is variably superior by nil close to classes of antihypertensive medication. A recent metanalysis of 22 clinical be appropriate to suggest that the people linking antihypertensive agents and happening diabetes is lowest for ACE inhibitors and angiotensinogen-receptor blockers, pursue by calcium channel blockers and placebo, with beta-blockers and diuretics have a diabetogenic effect.(4) ASCOT-BPLA ASCOT-BPLA was a major multinational trial involving done 19,000 hypertensive patients that compare the usefulness of two different conduct strategy at reducing cardiovascular dealings. The newer treatment strategy (amlodipine and perindopril) offered such recognized advantages over the elder treatment strategy (atenolol and bendroflumethiazide) that the trial was stopped precipitate by the Data Safety Monitoring Board in December 2004.

Episodic Migraine "Botulinum Toxin Type A Prophylactic Treatment in have a preference of Episodic Migraine Using a Modified Follow-the-Pain Treatment Paradigm: A Randomized, Double-Blind, Placebo Controlled, Phase II Study," Sheena K. Aurora, MD, et al. [PLATFORM SESSION II, #ABH0164: SATURDAY JUNE 25TH, 12:00-2:00 PM] -- Between-group differences (BOTOX® vs. placebo) on the primary efficacy measure (i.e., mean change from baseline in the numeral of migraines for 30 days prior to day 180) did not reach statistical significance.

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