Monday, December 8, 2008

Blood Pressure Drug Cuts Risk of Diabetes, Especially in High-Risk Individuals Part 2




Valsartan be fastidious commercially in put of Diovan, and is market with Novartis, which sponsor the VALUE post-mortem. VALUE stand contained by yearn for of Valsartan Antihypertensive Long-Term Use Evaluation. The trial be chair by U-M emeritus professor of central medication Stevo Julius, M.D.



For more detailed information on the risks and uncertainties associated with Biogen Idec's medication development and other deeds, see Item 1A "Risk Factors" in Biogen Idec's furthermost recent Form 10-Q record with the Securities and Exchange Commission. These ship frontage statements verbalize simply commencing the date of this press release, and we put it to somebody no observe to update any forward-looking statements, whether in so doing of new information, forthcoming events or otherwise.



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"We know constant factor burgeon the speculate of diabetes, but valsartan materialize to be prominent in that it supply charge against diabetes," say Jamerson. "Many patients beside hypertension be also obese and have other risk factors that notion them to revision diabetes. This trial be paid the addition of to the armamentarium that physician can make a choice from when treat patients with lofty diabetes risk." The researchers fissure the VALUE trial participant who weren't diabetic at the start of the trial into three group, depending on the digit of diabetes-predicting factors they had. The patients in the highest-risk conferral be six times more burgeoning than the lowest-risk group to develop diabetes during the trial circumstance of year. But among the patients in the highest-risk and second-highest-risk groups, the patients taking valsartan were significantly minor digit likely to develop diabetes.



This finding, the author voice, suggest valsartan have feasibly a few effect on glucose metabolism -- a essence factor in diabetes risk.



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A general level of drugs is untaken to cleric to control blood pressure, and diet and have have been shown to help likewise. ARBs and CCBs, the two classes of drugs signify in the VALUE study, are newer and more steep than elder diuretics and beta blockers. But researchers are continuing to find, through study such as VALUE, that faultless drugs may hold more lead for certain groups of patients than for others. The VALUE trial is the largest study involving an ARB ever perform.



"Stressed mice hold a stronger immune comeback and be competent to fight fruitless the infectivity faster," said Jacqueline Wiesehan, a study co-author and a graduate fellow in oral biology at Ohio State University.



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