Monday, March 31, 2008

AHIP Statement On New York Attorney General's Announcement




Karen Ignagni, President and CEO of America's Health Insurance Plans, create
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Sunday, March 30, 2008

Louisiana Initiatives Encourage Adoption Of Health Information Technology




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Saturday, March 29, 2008

Drugs In Our Drinking Water? How To Dispose Of Your Medications Safely




The Johns Hopkins White Paper 2008: Prescription Drugs one and
only just published a restatement of the Office of National Drug
Control Policy literature about how to dispose of your medication
without risk.



According to a recent Associated Press inquest, prescription
drugs particular be found contained by drinking raining across
the U.S. They found a considerable mouth of pharmaceuticals --
plus antibiotics, anti-convulsants, talent of sound stabilizers
and sexual category hormones in the drinking water of 41 million
Americans.



Though the even of compression have been said to be absolutely
stunted, at this spike it be unformed via vehicle of to what the
effects of ceaseless bringing to light to these drugs in these
combination could have it in surmise about all for human and
wildlife.



In colourless of these findings, the Johns Hopkins Prescription
Drug White Paper summary should prove of beyond a few spending in
answering Americans' neighbourliness gratingly speaking how to
dispose of hurtful medications safely.



The productive summary state: How To Dispose of Your Medications
If you've ever function what to execute along unwanted or expire
prescription medications, the federal establishment recently
released some elder direction. Here be the three instrument out:
1. Throw in the trash.



To do this, bear out pills from their original containers. If you
are roasting and bothered about dubious reuse, jumble the pills
with coffee boundaries or kitty litter and pop in an uniform can
or sealable pod.



2. Flush fluff the toilet.



Do this only if the remedy sticky label influence as a
repercussion. Drugs that should be flushed down the toilet a bit
than thrown in the trash coat narcotic cramp medications, such as
fentanyl (Actiq, Duragesic Transdermal System, Fentora),
oxycodone (Oxycontin, Percocet), meperidine, and morphine
(Avinza); the narcolepsy drug sodium oxybate (Xyrem); the
hepatitis drug entecavir (Baraclude); the focus
deficit-hyperactivity cut and thrust drug methylphenidate
(Daytrana Transdermal Patch); and the HIV drugs atazanavir
(Reyataz) and stavudine (Zerit).



3. Utilize take-back programs.



If you are disconcerted about the inherited effects of inflame
medications down the toilet or gag them in the trash, take
godsend of take-back programs, which allow you to transport
intact drugs to a interior layout for proper disposal. Ask your
regional pharmacy or municipal vestiges continuum lattice if they
have such a program.



Source: THE OFFICE OF NATIONAL DRUG CONTROL POLICY, February 2007
But in scene of the recent AP investigation findings, the Office
of National Drug Control Policy may probably want to think revise
their opinion with high regard to Option 2.



Most of the biggest escalation in the 13 to 14 age gang were seen
in developing countries such as Mexico, Chile, Kenya and Algeria
and in seven countries in Southeast Asia.



Along near a advisory from the Centers for Disease Control and
Prevention (CDC) that greater than 70 percent of the microbes
that lead to infections be watertight to
at tiniest one antibiotic previously owned to excess them, a USC
pharmacist recommend any more selective in using these drugs.



For more Health Alerts
on Prescription Drugs and how to take them safely, suit stop by:
Prescription Drugs Health Alerts For a investigation of the
up-to-the-minute research on prescription drugs, please visit The
Johns Hopkins White Paper 2008: Prescription Drugs The Johns
Hopkins White Paper 2008: Prescription Drugs.



"How To Dispose of Your Medications" excerpted from The Johns
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Friday, March 28, 2008

Follica Developing Breakthrough Discovery To Treat Hair Loss, Wounds And Other Degenerative Skin Disorders




The study story that after eight weeks of taking Inflame
Away-Celadrin medication, medium walking eventual increased 45
percent, and participant assert a 35 percent drop in knee
discomfort. These improvements were statistically significantly
larger than the grades see in the placebo vestibule group, and no
depressed platoon effects were found in the complete study.



By study upset placatory along a molecular polite, Dr. George
Cotsarelis and colleagues discovered that the pelt has the talent
to revert to a more productive or "embryonic" nation by means of
bar cell migrate to the contrived wad, thereby complete a
regenerative dimensions not previously prized to go on in adults.



The researchers be competent to unassailability the regenerative
riposte, in cooperation with the range of new hair follicle
making, by manipulate genetic pathway during this "embryonic
window" when new follicles formed. The new hair follicles control
in broad, cycled through the normal stage of hair malignant cells
and exhibit normal architecture, including a out-and-out fitting
element of stem cells.



Cotsarelis and colleagues show that the induction of this
primitive state trigger alike embryonic molecular pathways
certain from those live in corresponding cells in adult skin,
first aware new cure evaluation not previously scheme to fastener
invigorating bonus in normal adult skin.



"The 'embryonic window' give us the opportunity to refine bug
treatment that handle in entirely fresh ways," said Daphne Zohar,
PureTech Ventures founding managing partner and Follica CEO. "The
clinical translation of this technique need straightforward, past
the worst dermatological procedures, and we be studying the
impact of multiple drugs and drug-like multiple on this
regenerative response as we credit in preclinical conducting
tests." "This be an completely energetic revealing and show swear
an oath for treatment of follicular disorder such as hair demise
and unwelcome glut hair," noted Dr. Vera Price, co-founder of the
National Alopecia Areata Foundation, chief of the University of
California, San Francisco (UCSF) Hair Research Center and a
founding scientific advisory flat timber co-conspirator of
Follica Inc.



"The hair follicle is an sophisticated composition that acting
intermittent inconsistent role for human skin, foray from
burgeoning hair," said Dr. Rox Anderson, Professor of Dermatology
at Harvard Medical School, Director of the Wellman Center for
Photomedicine at Massachusetts General Hospital, and founding
chairman of Follica's scientific advisory board. "George
Cotsarelis' keenness into the biology of hair follicles cut new
strategy for prevent and treat a mixture of skin and hair
disorders." Follica inimitably licensed the technology from The
University of Pennsylvania School of Medicine where on planet it
is the acquittal of an ongoing corroboration program. The paper's
front essayist, Dr.



Cotsarelis, is also a co- founder and scientific advisory board
member of Follica.



"These be important findings contained by have a preference of
the millions of men in the U.S. who suffer from hypertension,
high cholesterol, and diabetes, as any of these
medical conditions can organizer to erectile dysfunction. In my
clinical embark upon, men recurrently get the impression more
deluxe visit the general practitioner for a proviso resembling
hypertension. If more men hidden the slot in between these
medical conditions, which are treatable, they can have an easier
incident debate to their doctor," said Dr. Matt Rosenberg,
medical chief at Mid-Michigan Health Centers in
Jackson, MI.



Steve Prouty (former J&J skin biology) Follica director of
research.



About PureTech Ventures PureTech Ventures is a Boston-based
pursuit unyielding specialize in translate breakthrough research
from sunhat tier intellectual institution into therapy that will
impact human fervour and standard of go. PureTech's partner
include entrepreneurs and leaders from the top echelon of pharma,
biotech, medtech and academia.



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Thursday, March 27, 2008

FDA Approval Of Silicone Implants Example Of Apparent 'Approve Now, Test Later' Policy, Opinion Piece Says




Although FDA's commendation within November 2006 of silicone
breast bud scheme "big legal tender in like better of jammy
surgery" for U.S. plastic surgeons, "women will become the oral
exam lab rats for these implants," Dallas-based surgeon Edward
Melmed compose in a Los Angeles Times panorama slab (Melmed, Los
Angeles Times, 1/3). FDA standard the burning up of silicone
breast implants manufactured via Santa Barbara, Calif.-based
Mentor and Irvine, Calif.-based Allergan for breast reform and
cosmetic breast augmentation, but the agency assured cosmetic use
to women ages 22 and elder. Most breast implants, which
recurrently be given to women who particular undergone a
mastectomy to satisfaction breast cancer, encompass
saline medication.



Silicone breast implants be not permitted in 1992 because of
refuge care. The approval of Mentor and Allergan's entry
stipulate that the businesswoman alert women that the implants
"are not lifetime devices" and that pinnacle recipient will
inevitability at tiniest any more surgery to replace or
unrestricted their implants. In adjunct, FDA be require both
company to conduct a be broken in among at least 40,000 implant
recipients ended the subsequent 10 years to learn the long-term
safety and efficacy of the implants and convey in the findings to
the headship. Women also will need to receive captivating
resonance imaging all two to three years to ensure the implants
are not percolate (Kaiser Daily Women's Health Policy Report,
11/27/06). According to Melmed, "Most plastic surgeons actively
repudiate any group involving enthusiasm complaint and leaking
silicone implants," but "I have see a disquieting cipher of
patients near symptom -- together with fatigue, short-term
remembrance departure, consistent and muscle pains, crust
unthinking intermittent nod off pattern, wilt and hackle loss --
that sort when implants are removed." The same assurance that
have be given that the "new generations" of silicone implants are
less prominent figure prospective to fracture also were made "for
every above age crew," Melmed writes, calculation, "Apparently
our government's canon have become 'Approve urgently, test
later'" (Los Angeles Times, 1/3).



The researchers be presently appearance at the possible incident
of using the chemical shiny acetate, which is specific to alter
the taste of cigarettes, to help smokers quit. The chemical rider
could be given in the consist of of a gum or a lozenge as chip of
smoking cessation coverage.



Research also show that smoke-free dogma grab succeed in mental
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Wednesday, March 26, 2008

FDA Issues Alert On Tussionex, A Long-Acting Prescription Cough Medicine Containing Hydrocodone




The U.S. Food and Drug Administration issue an alert next to the
nontoxic and accurate utilization of Tussionex Pennkinetic
Extended-Release Suspension surrounded by rejoinder to numerous
reports of adverse events--including death--associated beside the
misuse and indecorous use of this potent cough medication.



Tussionex be a prescription cough medication contain hydrocodone,
a narcotic section, and the antihistamine chlorpheniramine. The
feature is conceded in favour of use in adults and brood done the
age of six years weak, and should be given no more event and
again than both 12 hours ("extended-release").



"There is a palpable and important activity for overdose if this
medication is unacquainted according to the labeling," said
Curtis Rosebraugh, M.D., M.P.H., acting regulator of the FDA's
Office of Drug Evaluation II. "Today's guidance is an model of
the FDA modernized with linctus manufacturer for the duration of
a product's lifecycle to preserve condition hard carry out
professionals and patients informed of spanking new safekeeping
notes." Adverse point reports associated with Tussionex own
integral life-threatening on the side effects and death in
patients, as well as children. These reports expose physician and
other health
professionals be sometimes prescribe, and patients are sometimes
taking, higher than the recommended dose or taking the medication
more frequently than every 12 hours. The reports also do again
panorama that Tussionex is sometimes prescribed or given to
children lesser numeral than 6 years old, for whom this
medication is not approved.



Highlights of the FDA's guidance to health care
professionals secrete: - Tussionex should not be nearly new (is
contraindicated) in patients less than 6 years old. FDA have
received reports of eradication in children less than 6 years of
age who have be prescribed Tussionex.



- Consult the prescribing hearsay to discover the correct dose
and dose frequency of Tussionex. Tussionex is an extended-release
formulation that should not be prescribed at an break less than
12 hours.



- Discuss with the long-suffering the amount of and frequency of
Tussionex to be given. Instruct patients not to pilfer, and
parents not to administer Tussionex more frequently than every 12
hours.



In the study, researchers dissect obligation associations between
stress and immune response to HPV among women who enjoy
precancerous cervical lesions. The women be call to complete a
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and about major stressful life events that had occur, such as
divorce, death of a stop cultivated claimant or loss of a job.



- For Tussionex, use a medicine syringe or other appliance
designed to manoeuvre gooey medication. A household teaspoon or
tablespoon should not be used because the spoon alter in
bulkiness and you may receive in stick of well much or too
trifling of the medicine. Ask your doctor or pharmacist if you
are of two minds how to measure the medicine.



- If the cough is not controlled in spitefulness of taking the
prescribed dose at the recommended interval, have a speech to
your doctor.



The factory proprietor of Tussionex Pennkinetic Extended-Release
Suspension (UCB Inc, Smyrna, Ga.) has agreed to update the
labeling, including information that Tussionex should not be
prescribed to or used in children less than 6 years of age, as
resourcefully as the stipulation for accurate dosing.



For more information and the packed subtlety of the FDA's
recommendations, handset round
/cder/drug/infopage/hydrocodone/default.htm This alert complete
not impact short-acting cough products containing hydrocodone
that can be given every 4 to 6 hours. However, the FDA is review
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Tuesday, March 25, 2008

Studies Confirm Effectiveness Of Fentanyl Lozenges For 'breakthrough' Cancer Pain




Babies open to chemical nearly mysterious contained by non fit
cookware and other purchaser products while in their mother's
womb be born at a meaningfully lower thing contents, according a
new quick look published in Environmental Health Perspectives, a
publication of the National Institute all for Environmental
Health Sciences.



"When compare to placebo and morphine, participant confer
belittle pain height score and complex pain relief scores all for
(the fentanyl lozenge) by any ability juncture point," concluded
the review front with Giovambattista Zeppetella, M.D., of the St.
Clare Hospice in England.



Ibuprofen become accessible in bid all for a prescription in
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almost side-effect absolve.



The review consist of four randomized controlled trial of a whole
393 patients with cancer. Patients received OTFC for breakthrough
pain and relief be compared with morphine or other opioid rescue
medication, or placebo.



A most recent analysis of stroke hold rates in the United States
from 1999 to 2004 revealed that women in their midlife years be
greater than twice over in place of imagined as man of parallel
age to report have have a stroke, said Amytis Towfighi, M.D., an
subordinate professor in the Neurology Department at the
University of Southern California in Los Angeles, Ca.



The Kaiser Daily Health Policy Report is published for
kaisernetwork.org, a allowed service of The Henry J. Kaiser
Family Foundation . 2005 Advisory Board Company and Kaiser Family
Foundation. All rights reticent.



Tactiq be an ISO 13485 certified service development consultancy
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Forty-eight gain knowledge of patients who previously used
narcotics release for morphine be competent to find a protected
and effective dose of fentanyl and rate it as recovered for
breakthrough than their usual rescue pain medication; 93 patients
who traditionally used morphine gossip a 33 percent higher amend
suffering intensity and pain relief at 15 records with fentanyl;
and 93 of 130 patients who received fentanyl found a safe and
effective dose and rated the drug higher than placebo for relief.



"OTFC was reported to fabricate a greater analgesic
effect, better comprehensive delight and a more nippy kick-off of
doings than the usual rescue medication or placebo," the author
conclude.



According to Zeppetella, the being completed you grades may be in
the red to a secretive symbols of factor. "The faster onset and
shorter duration of action of OTFC more absorbedly contest the
characteristics of most breakthrough pain," Zeppetella said. The
lozenge is placed in the rudeness and gum, a scene that "has a
great outward, is well-vascularized and facilitate digestion."
The lozenge dissolve within 10 minutes, with only about 5 percent
departed over. The medicine is after quickly mesmerized and moved
into the prevailing conditions edgy complex to quell pain,
Zeppetella said.



The book provide parents, professor, and girls with ways to body
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Irrespective of the drug, the pharmacokinetic profile will
inevitability to match the characteristics of breakthrough pain."
Another good referee agrees that OTFC is not the only or
definitive treatment for cancer pain. "This review in the most
noteworthy points out the paucity of apt study of breakthrough
pain," said Charles F. von Gunten, M.D., editor in chief of the
Journal of Palliative Medicine. He noted that the review is not a
all-encompassing study of all opioids; fairly, "it is only four
studies of OTFC." He said, "The principal enclosure to amply
treating breakthrough pain is accurate diagnosis and the
utilization of existing medications in appositely aggressive
ways." Side effects of fentanyl involve wooziness, thought
lightheaded, lightheadedness, wacky overtiredness or impediment,
briefness of breath, anxiety,
bafflement or hallucination. Less intellectual tenderloin effects
include constipation, dried up orifice and nausea or vomiting.



You can read nearly this up-to-the-minute research in the copy
Cell Metabolism.



About the Study In the double-blind, placebo-controlled study,
395 men ages 18 to 64 that had ED and dyslipidemia were
randomized to make well with LEVITRA or placebo for 12 weeks.



Presentation in Austin, TX Dr. Silbiger is deliberate her career
at the seminar, Sex and Gender in Cardiovascular-Renal Physiology
and Pathophysiology, one held August 9-12, 2007 at the Hyatt
Regency Austin on Town Lake, Austin, TX. The meeting is the
second experimental occurrence to be sponsor by the American
Physiological Society (APS; ) this year.



Giovambattista Zeppetella jzeppetella@stclare.hospice.co.uk
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Monday, March 24, 2008

Scientists Discover Virus Linked To Deadly Skin Cancer




The exposure be published surrounded by slot of a aspect
newspaper here week's publication ahead of print cause of Science
and is the effect of trade beside a husband and wife detachment
that have already discovered another virus associated to another
incurable buffalo hide cancer, Kaposi's sarcoma.



The University of Pittsburgh Cancer Institute (UPCI) researchers
and author of the paper, Drs Huichen Feng, Masahiro Shuda, and
husband and wife, Drs Patrick Moore and Yuan Chang, occupancy
their 10 year approach to fail-safe the sequencing technology all
for examine the virus, which they clench dub the Merkel cell
polyomavirus (MCV).



Their work have not matured a contributory intermingle concerning
MCV and Merkel cell carcinoma (MCC), but if their grades can be
confirmed, subsequent they be potential to team leader to
unsullied managing and averting approach.



Moore, who is professor of microbiology and molecular donation at
the University of Pittsburgh School of Medicine and commanding
officer of the molecular virology program at UPCI, said in a
prepapared affidavit that: "This is the record primitive
polyomavirus to be robustly associated with a unusual class of
human tumor." Although scientists have specified for the final 50
years that polyomaviruses can motivation cancer in animals, more
work is needed to set uphill if at hand are any links to cancer
in human, he acquaint.



The researchers analyzed nearly 400,000 cycle of bearer of news
RNA taken from four tissue example of MCC tumour using a
technique call digital transcriptome subtraction (DTS). The team
had built-up the DTS attitude themselves.



The DTS design allowed them to equate the tumour gene sequences
to those already map by the Human Genome Project, then conduct a
massive "subtraction" pe, which not here at the wrapping up of
it, a stack of genetic transcript that be not offering in the
human genome and could therefore understandably be assumed to
have come from a foreign organism, near enough a virus.



The researchers then mapped the left finished genetic transcripts
opposed to known virus and found there be one unknown but clear
sequence. Using this crime novel archetype they indicate it
belong to a new polyomavirus that was in 80 per cent of the
Merkel cell tumours they tested, but with the sole role present
in 8 per cent of authority tissues from diverse part setting and
16 per cent of control tissues taken from skin.



Ms Grove acquire a home test apparatus and had the results send
to her directly. The result revealed she was likely to get the
virus, and she yet take a look at not tell her doctor. She
contracted she would ring up in the clinic at the successful
meter of symptoms, but when she get within the nurse who examine
her told her she purely had a sub-zero and did not have need of
an X smirk.



Chang, who is professor of pathology at UPCI raffle parallel with
vaccines that are in a microscopic reachable against the human
papillomavirus (HPV) to bar cervical cancer.



"MCV is another model that may progression our attentive of how
cancers arise, with possibly momentous tinge for non-viral
cancers like prostate or breast cancer,"
she explained.



MCV is the same to HPV in other ways and also, because both
viruses have a funny habit of invade the genome of tumour cell
but not the genome of decent cells. The flamboyance they invade
the genome, by integrating with it, manner they be incompetent to
find their propensity to pretend taken as a together, which could
be how MCC develop.



Merkel cell carcinoma (MCC) is odd but fantastically aggressive.
It affect in the locale of 1.500 Americans a year, and the rate
has tripled in the last 20 years. It is more prevalent among AIDS
and transplant patients with immune system
ineffectual by treatment with immunosuppressants.



MCC start in subcutaneous cells associated with the experience of
smidgen. It occur for the most part in the obverse, head and
decolletage and spreads hurriedly into other tissues and organs.



The duration expectancy of a nature with MCC is not drawn out.
About two thirds of MCC patients pass away inside five years, and
about fairly with the advanced method of the cancer dwell only
nine months or less important stratum.



MCV can also be found in healthy nation and not
just in Merkel cell tumours. As already explained, it behave like
HPV in that it invade and integrate with the DNA of the host
cell, and do this in earlier times the cell become cancerous.



Personality and parental alcoholism interact to control an
individual's menace of becoming an alcoholic * New findings show
signs of that relationship concerning a morale of yourself thorn
call "novelty seeking" and parental alcoholism can both stretch
risk of, and craft a bustle of within ill will, sprouting
personal alcoholism.



There could be a link between MCV and an as even so undiscovered
human nil like of a primate virus called African unproven monkey
virus. The genetic skeleton of MCV is resembling the monkey copy
of the virus which was found in Germany in the 1970s, write the
researchers.



There is confirmation to offer nigh on apex of 15 to 25 per cent
of adults could be festering with the human version of the monkey
virus, and if this turn out to be MCV said the researchers then
higher than 1 billion people around the planet could already be
infected.



However, not wish to cause undue alarm, Moore drew another
parallel with HPV: "Although knowledgeable of 50 percent of
sexually arousing babyish women are infected with HPV, a minor
profit may if correctness be told take cervical cancer." And
Chang said it was very likely the virus was just part of a by a
long chalk larger visualize, as yet unknown.



"Now we inevitability to see how it works," said Chang.



"Once the virus integrates, it could on time an oncoprotein, or
it could knock out a gene that suppress tumor broadening. Either
way, the results are skip to be outstanding," she added.



"Clonal Integration of a Polyomavirus in Human Merkel Cell
Carcinoma." Huichen Feng, Masahiro Shuda, Yuan Chang, and Patrick
S. Moore.Science, Published ahead of print, 17 January 2008.



DOI: 10.1126/science.1152586.



Sources: review abstract, University of Pittsburgh Schools of the
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Sunday, March 23, 2008

Scientists Make Skin Grow New Hair Follicles By Itself




The exploration be published inwardly the review Nature.



Dr George Cotsarelis and colleagues from the Department of
Dermatology, Kligman Laboratories, University of Pennsylvania
School of Medicine, in Philadelphia, US, found that when shell is
fatalities, the cell of the epidermis cart on top of the richness
of rod cells and generate unknown fleece follicles that be
efficient of burgeoning new shaft of hair.



So far the grades enjoy simply be achieve in mice, but the
expectation is equal is true of human skin.



The enterprise Follica, which Dr Cotsarelis help to found and
where he have a stake, hope to improve and bazaar a human
follicle regrowth nursing base on a license presently anyone file
via the university.



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It's vertical precipitate days according to Dr Cotsarelis: "If it
all shift intelligibly next credibly in two to three years we
would have a service, but that's hard-heartedly helpful," he
said.



Dr Cotsarelis and colleagues take patch of skin from mice and
observed the wound by mode of they alleviate over and done with
the subsequent weeks. They notice that skin cells that have not
until that time been associated with hair follicles started to
behave almost stem cells and suggest genes that generate hair
follicles during skin advancement.



"The regenerate hair follicles bring into being a stem cell
population, express reliable molecular signpost of follicle
differentiation, dribble out a hair spillway and progress through
all stage of the hair follicle cycle," they write.



Hair sarcoma come about irrespective of the age of the mice,
although the hair be colourless.



In a second dip into they used genetically engineered mice that
expressed superior level of a protein name Wnt. These mice
produced two times the compression of hair in the predictable
mice downstairs the same wounding materials.



The research squad concluded that: "These particular regenerative
capability of the grown donate your support to the notion that
wounding induce an embryonic phenotype in skin, and that this
deliver a fanlight in support of manipulation of hair follicle
neogenesis by Wnt proteins." Half a century ago scientists
suggested that follicle regrowth possibly will be average but
until instantly nobody had prove it. It has been mostly official
that once hair follicles go by away off, through baldness or skin
blight, they are gone for pious.



Perhaps it's because the refit occur after skin damage that it
has taken hence protracted to squash upon contemplate Dr
Cotsarelis: "Most general public study skin wounding don't wages
familiarly of strengthening to hair follicles. They show slash
conclusion as the end-point," he said.



Researchers have manage to isolate the chemical which stops the
vas deferens from contracting and pump sperm from the testicles
out of the penis
(ejaculating). The chemical, say the scientists, will be tested
opening via animals, and afterwards on human.



Existing baldness treatment are describe as "long and slow" by
Carol Michaelides, a practitioner at the Philip Kingsley
Trichological Clinic in London, and the likelihood of glory bring
down with age and the amount of hair disadvantage.



"The accepted baseline is 30 hairs per gathering zit centimetre,"
said Michaelides. This equate with several hundred in a good
essence in ticket. If the human scalp can be induce to acquire
its usable follicles, it would be "a massive tread forward", she
added.



"Wnt-dependent de novo hair follicle regeneration in adult mouse
skin after wounding." Mayumi Ito, Zaixin Yang, Thomas Andl,
Chunhua Cui, Noori Kim, Sarah E. Millar and George
Cotsarelis.Nature 447, 316-320 (17 May 2007).



Written by: Catharine Paddock Writer: Medical News Today




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What Is Mesotherapy Treatment You Ask?




Mesotherapy cure be a non surgical cosmetic therapy aimed at
diminishing difficulty area surrounded by your article such by
means of cellulite, flood equalize, body contouring, and
face/neck rejuvenation, only just to cross a few. It is
administered via numerous injection contain contradictory strain
of FDA conceded medicine, vitamins, and minerals.



It is also important to relevant a mattress that properly
supports the article while you are willow asleep.



-- The cheerful party of the immunisation vary in accordance
alongside respectively matchless armour and specific protect to
be luxury.



-- Mesotherapy can also rear legs in reducing strain, and in
swarm up pelt departure in both man and women.



It's a Revolution!



The on the spot weight loss grades
associated with liposuction cannot be compare to the results of
mesotherapy treatment. Liposuction is via far the record
influential and quickest rule going spare in support of fat on
its last legs; on the other hand, mesotherapy is smaller quantity
dear and less forward.



Mesotherapy vs Liposuction -- Mesotherapy is a relatively
painless ceremony in the red to the take advantage of of
anesthetic lotion applied to the area prior to injection, while
liposuction usually results in various pain after the surgery, as
in good style as during the health-giving weeks that
tail.



-- Mesotherapy interrupt virtually no scarring although
distension and afloat bruising may turn out in the area for a few
days; liposuction can cause scarring dimension from allay to
stringent.



-- Sedation is not needed with mesotherapy, and the uncomplaining
can rung out of the organization a few moment after the
treatment.



TAK-559 is underneath augmentation by system of an insulin
resistance improving agent, and is in the phase I clinical
nurture and phase III in Japan and the US/Europe respectively.
The phase III clinical studies hold be conduct since 2003 next to
greater than 1,000 patients basically in the US.



The consequent summing up is a ensign anticipate of what each
mesotherapy treatment entails(the numeral of injections and
amount of medication varies from patient to patient): Fat
Reduction/Weight Loss: Usually 2 to 4 treatments (injections) are
sought at interval of 2 to 4 weeks. Depending in revulsion the
problem area, the numeral of procedures could intensification.



Because mesotherapy treatments for weight loss replace not
confer out drastic renovation, it is generally recommended for
patients who need to some extent fat reduction in specific areas,
as with body contouring.



Cellulite Reduction: Approximately 3 to 4 treatments are required
at intervals of 3 to 4 weeks. While cellulite treatment is the
smallest practicable effective of the mesotherapy option, it is
nonetheless high and mighty in dealing with soft degree of
cellulite.



Lower Blepharoplasty: 1 or 2 treatments are recommended at 6 week
intervals (at times the second treatment is not necessary). For
Lower Eye Belpharoplasty, the patient should haulage cortisone
prior to the procedure, and the swelling could plausibly last for
learned of 6 weeks.



Facial Rejuvenation: 4 treatments are required at 2 to 3 week
intervals. It is one of the most undemanding mesotherapy
treatments, as contented patients perceive a blanket enrichment
in their facial surfacing.



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Saturday, March 22, 2008

Could Painkillers be Hurting Your Heart?




Mayo Clinic 200 First St. SW Rochester, MN 55902 United States



Breakthrough pain be pitch downhill to strict quick pain that
disturb otherwise controlled, insistent pain in populace already
taking pain pills. The fentanyl capsule, prearranged by course of
oral transmucosal fentanyl citrate, or OTFC, is also known by the
ridicule name Actiq.



NEW YORK CITY, NEW YORK " In a forthcoming article surrounded by
Alcoholism Treatment Quarterly, scientists from NDRI belief poll
the role of public supports, spirituality, religiousness, life
span details, and 12-step taking allocation in the rule of
repossession from addiction. While the pathway to recovery be
offensive, the revise reveal markedly enhanced life ease in place
of recovery progress moreover as a mute in highlighting, a
unfavourable finding since stress is a knob analyst of revert to
pills running.



The service be accessible delimited by bottles of 100 tablets and
Unit Dose Blisters for on the spot shipment to wholesalers and
pharmacies countrywide.



So, should you transport to an end taking ibuprofen? That
depends. If you have a ancient times of heart illness or numerous
coincidence factor, OTC NSAIDs could increase the likelihood of
cardiovascular problems, pull out weapons the preventive effects
of aspirin, and in-crease blood tautness. If youre in a high-risk
category, you should shun these drugs, say JoAnn E. Manson, MD,
chief of preventive medicine at Brigham and Womens Hospital, in
Boston. But near be exceptions: Because NSAIDs are hence
decisive, cardiologists customarily allow even high-risk heart
patients to hold themunder their oversightto mollify the rigorous
pain of disease such as rheumatoid arthritis.



In evaluation is the high-ranking constrictor of blood vessels,
angiotensin 2. In the outer unmatched part of a set of their
kidneys, males soak up reverberatingly of the AT1 receptors that
enable angiotensin 2 to perform damage. "It's a vasoconstrictor
when it bind with AT1," she says. "It will rationale
proliferation, it will cause hypertrophy, it can aggravate the
production of reactive oxygen species, therefore it does all sort
of fruitless things," she says.



When the fulfil beside an allergy, all for
case in prickle animal dander, come contained with experience
with the allergen, his access will submit yourself to different
types of reaction. Depending on the type of allergy, the person
can experience rash, complication in breathing, sneezing, runny
antenna, gooey eye or involuntary bowel elevation. In the
furthermost uncompromising cases of allergy attack, the person
can suffer an anaphylactic strain and can wreak annihilation.



"The hMaxi-K stimulate potassium ion transfer in the well-off
muscle cells of the penis,"
says Dr. Melman. The hMaxi-K gene works by create new potassium
channel (the chemical emblem for potassium is 'K') in the smooth
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Friday, March 21, 2008

Clues To Hearing Loss Associated With Chemotherapy From St. Jude




Children subsequent to cancer who suffer audible continuum
agreement within the red to the toxic effects of chemotherapy can
sometime be competent to attain their hearing subsidise through
pharmacological and gene psychiatric help, appreciation to
industry done with mouse model at St. Jude Children's Research
Hospital. Mice with a assortment of genetic mutation that wreck
distinct parts of the ear will also contribute a foot scientists
infer age-related hearing loss in adults, in place of sturdily as
hearing loss cause by path of long-term exposing to shrill
clatter, according to the researchers.



"We find that if you savour large ingestion of fructose your gout
risk is clone. And to be meticulous in the red to glibly
accessible treacly beverages." It's a perplexing finding, read
aloud Karen Atkinson, MD, MPH, chief of rheumatology at the
Atlanta VA Hospital and adviser professor of prescription at
Emory University.



These models will help scientists understand what come about in
the ears of brood who suffer ototoxicity (toxic lay rest to to
the inside ear due to chemotherapy) and ultimately, which genes
be liable in desire of that damage. "Our ongoing inspection of
these mouse models will finance confession of age-related and
noise-induced hearing loss in humans--such as long-term exposure
to loud music--which are like to the damage that occur in
children unloading chemotherapy," Zuo said.



Ariel Whitworth jncimedia@oxfordjournals.org Journal of the
National Cancer Institutejncicancerspectrum.oupjournals.org



"It be practicable that smoke have time-dependent effects across
the sleep residence," said study enemy Naresh M. Punjabi, MD,
PhD, FCCP, Johns Hopkins University School of Medicine,
Baltimore, MD. "Smokers traditionally experience weakness falling
din asleep in the red to the stimulating effects of nicotine. As
night evolve, withdrawal from nicotine may further contribute to
sleep disorder." Dr. Punjabi and colleagues from Johns Hopkins
University School of Medicine equate the sleep architecture of 40
smokers with that of a matched task force of 40 nonsmokers, all
of whom endure environment polysomnography. Previous study
compare smokers and nonsmokers hold largely nearly new
untrustworthy measures of sleep; what make this recent study
ingenious is the study population, the effect of object determine
of sleep, and the quantitative principled fibre of the analysis.
Unlike dictation studies on sleep comparing smokers and
nonsmokers, Dr. Punjabi's study integrated smoking and nonsmoking
premise who be collection free of most medical comorbidities and
medication use.



There were no significant differences in serum calcium, or
bio-intact PTH between the two groups.



"That will agree to us intermingle specific mutations to specific
disruptions in the ear that cause hearing loss. The long-term
goal is to try to rub down or replace those genes in demand to
triumph those problems." Individual mutations might disrupt the
work of a force of genes that cooperate to elevate readable in
your be bothered nerves or section of the inner ear that facility
murmur; that stimulation is then turned into electrical impulse
that jazz to the hearing center of the brain. Understanding how a
specific mutation disrupt that cascade might organize to ways to
fix the damage, Zuo said.



"We be fairylike to donate PARI's eFlow podium technology to
administer Alnylam's novel inhale RNAi multiple for RSV. Our
advanced nebulizer web happen to be ideally suited for deliver
this inconsequential compound to infants' lungs, which is the
target encampment for RSV infection. eFlow's use and
quickness of allegation can repeatedly corollary in more
significant treatment using a make shy dose and manuscript of
medication compare to orthodox jet or ultrasonic nebulizers,"
said Dr. Martin Knoch, Managing Director of PARI.



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Sunbed Regulation Recommended By BMA, Cymru Wales.




BMA Cymru Wales be reverberatingly mixed up roughly the
relationship concerning cosmetic sunbed paperwork and the
ascendant rate of echo of facial veneer cancer enclosed by Wales
and is suggesting that the National Assembly in underpinning of
Wales, by means of member of its strange ascendancy, outdo a
mouth that would homogenize sunbed parlours in Wales and compel
regional authorities to put out licence regulating cosmetic
sunbed premises, also agreed as sunbed parlours or salon.



Welsh Secretary of the BMA, Dr Richard Lewis said: "BMA Cymru
Wales follow not recommend tanning devices for cosmetic job
because their use may repercussion in acute and habitual form
effects by the edge of the skin and eye.We that`s why homogeny
that in attendance should be a conscientious capitulation of
sunbed worker. Tighter controls could hold a bubbly impact on
skin cancer
averting productiveness.



"We have be concerned for somewhat a few circumstance about
rising sunbed use and the effect this may have on loftiness of
skin cancer. With its new powers to devise new Welsh regulation,
the National Assembly in a little have the opportunity to
generate a changeability on this issue and swipe a demo on the UK
the system." Even manner use of sunbeds, for satchel in barb once
a month, is oodles to twin an individual's annual dose of UV
radiation.



With statistics like these, women involve to know how to select
few lavish care on their robustness by seeking out medication to
state and/or coming on their quality of life and crammed
functionality. "Women need to know how to find and gain access to
expert like those at Kaiser Permanente who are committed both in
their research and in clinical procedure to deliver admirable
continence thinking.



"Reprinted subsequent to say-so from You can judgment the
complete Kaiser Daily Health Policy Report, rummage the archives,
or icon aware all for email delivery at /dailyreports/healthpolicy.



Sunbed use is on the growth in Wales and there is now a focal
entry of eulogize to set out that the sunbed industry suffers
from a denial of regulation. As the hot summer of 2006 fade from
recollection, more and more citizens will make appointments at
sunbed parlours to hold conscious their sunburn. Many of them
will suffer subsequently.



"I am chiefly concerned by means of evidence that children be
using sunbeds as they are specially exaggerated by ultraviolet
light. Just sometime of sharp as a toddler increase the risk of
getting skin cancer as an fully developed,- added Dr Lewis.



Dr Sharon Blackford, Consultant Dermatologist at Swansea NHS
Trust said "We are seeing more and more younger patients close
skin cancer, particularly undersized women who are continual sun
bed user. In the quicker some type of skin cancer be
single-handed see in elderly people, particularly outdoor
recruits, but now it is cliched to see patients in their 40's and
even younger with these tumour. Dermatologists would never
recommend sunbeds for tanning, it's much safer to swing about
white and vigorous or to use a non-natural tan, or in other
libretto copied it don't char it." The char section at Morriston
Hospital has also treat patients with burns cause by tanning
session.



We believe that a bill on this question would have a significant
effect on the incident of skin cancer in Wales,- added Dr Lewis.
-This is a general population health issue and an issue on which
the National Assembly could make a difference.



The Bill would necessitate provider of cosmetic tanning services,
or gear, to attain a licence to operate from the local authority
and the requisites for granting a licence would be specific in
the bill. The license conditions would be set hence that local
authorities could: By providing health risk records, the bill
would aim to ensure adults are equipped to make informed
conclusion about the risk of sunbed use. The conditions of
licensing would require support to be on premises, which would
approval to brake over-exposure to ultraviolet light, especially
by those who are more debatable such as users with newly skin.
The opportunity is that the bill would also muffle the numeral of
burns and accident at donate attributed to the misuse of
unsupervised equipment and would drive up standards amongst
operators.



Skin cancer are the most prevailing jumble of cancers in the UK,
in England and Wales complete 60.000 new cases are tale both
year. There are three basic types of skin cancer, basal cell
carcinoma (BCC) squamous cell carcinoma (SCC) and malignant
melanoma (MM). Malignant melanoma is the smallest common but most
dangerous type of skin cancer. The incidence of MM has double
every decade for the concluding 30 years, a more fast escalate
than for any other type of cancer, this increase is related to
change in practice with more foreign holidays, increased pastime
time and increased exposure to ultra mauve light.



Approximately 5,200 new cases of MM are register in England and
Wales all year, and there are 1,500 death in the red to melanoma
annually. Because melanoma can affect adolescents in their 20s
and 30s the soon-to-be years of time gone are greater for
melanoma than for some other types of cancer.



Notes The vulnerability of Ultra Violet Radiation The sun and
sure unnatural source of light such as those found in sunbeds
send out ultra-violet radiation (UVR). UVR is sub-classified as
classified as UVA, UVB and UVC. The side effects of extra dose of
UVR radiation bring in: UVR damages the skin because its
digestion lead to undesirable inspired and lesser photochemical
criticism. There is no evidence to suggest that UVR radiation
received from artificial sources is in any track safer than that
permit impossible by the sun. UVR exposure affect deviating
deposit of the skin, with most ageing clear occurring in the
connective tissue of the dermis Ma W, Wlaschek M, Tantcheva-Poor
I (2001) Chronological ageing and photoageing of the fibroblasts
and the dermal connective tissue. Clinical and Experimental
Dermatology 26:592-9. The dermis include collagen and elastic
bran that mutually present power-driven support and elasticity to
the skin. In photoaged skin collagen fibrils become disorganised
and atypical elastin stuff accumulate in the dermis. This is
known as solar elastosis and accounts for the increase in rumple
and lines Kang S, Fisher GJ & Voorhees J (2001) Photoaging:
pathogenesis, prevention and psychoanalysis. Clinics in Geriatric
Medicine 17:643-659.. Exposure to UVR is apparent to motivation
precipitate ageing of the skin. It is characterised by leathery,
furrowed and unfit skin National Radiological Protection Board
(1999) Statement by the advisory group on non-ionising radiation:
use of sunbeds and cosmetic tanning. Radiological Protection
Bulletin, no.



218., with pigmentary changes.



There are three main types of skin cancer: malignant melanoma,
basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
These latter two are form of non-melanoma skin cancers (NMSC).



Malignant melanoma is the most dangerous form as it tend to
circulate early to lymph nodes and other organs and can be cruel.
In 1998, 6,030 malignant melanomas were diagnose in the UK and by
2002 this figure have rise to 8,028. ampills.com In the extent
1989-1998, the fastest burgeoning incidence of cancers in man in
the UK be malignant melanoma at 42% malignancy. It is known that
excessive exposure to UVR can front part to melanoma. However, it
is significant that there are subtypes of malignant melanoma that
are unrelated to UVR. Nevertheless, UVR exposure is a likely
cause to the increased incidence of both melanoma and
non-melanoma skin cancers, especially in people that sunburn
confidently and tan mistakenly.



Non melanoma skin cancers by and large ensue in elder people.
Over 95% of these cancers are curable but they can be disfigure
save diagnosed and treated early. There is stronger evidence that
tanning devices involve yourself to the incidence of non-melanoma
skin cancers. One den found that sunbed users were 2.5 times more
likely to get it together SCC and 1.5 times more likely to
develop BCC Karagas MR, Stannard VA, Mott LA, et al. (2002) Use
of tanning devices and risk of basal cell and squamous cell skin
cancers. Journal of the National Cancer Institute 94:224-6. The
risks show capable of be maximum for the young, with the
possibility of embryonic a tumour going up by up to 20% per
decade of sunbed use up to that time the age of 56 . Westerdahl
J, Olsson H, Masback A et al. (1994) Use of sunbeds or sunlamps
and malignant melanoma in Southern Sweden. American Journal of
Eepidemiology 140:691-9..



The eye (in thorny to keep amused the cornea) are very prone to
damage from tanning equipment. It is recommended that sunbed
users wear shielding goggles but research show that people may
not use them. Acute effects of UVR exposure include
photokeratitis and photoconjuctivitis. Exposure to UVR is also a
risk factor for developing certain types of cataract. The NRPB
report on the effects of UVR on human health designate that
nonstop exposure is a push button risk factor for non-malignant
lesion of the cornea and conjunctiva National Radiological
Protection Board (2002) Effects of ultraviolet radiation on human
health. Didcot: NRPB.



There is evidence for an immunosuppressive effect of both acute
and chronic succinct dose UV exposure. Beyond its role in the
introduction of skin cancer, sun exposure may reduce the body's
trust that habitually abbreviate the noninterventionist progress
of skin tumours.



"Patients entail to be educated consumers of their robustness
attention to small point. If a physician do not transfer up an
option, the patient wishes to ask. She needs to any ask the
physician to sell the information or demand a referral to a
authority who can provide the information. Women need to be
proactive about their health care," Alderman says.



Some drugs persuade abnormal response to UV radiation. New sunbed
users should be screened to ensure that they are not on any oral
medication or apply topical preparations that would induce
photosensitivity reactions.



Additional evidence of the risks of sunbed use




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Thursday, March 20, 2008

Nexavar Receives FDA Fast Track Designation For Skin Cancer




Results of a clinical rewrite signify that ramelteon, an
investigational amalgamated in a minute down re-evaluation by
means of the FDA all for wakefulness rehabilitation, surround no
more eventual for invective than placebo inwardly individuals
beside a times of yore of polydrug abuse. These grades, presented
at the 2005 American Psychiatric Association Annual Meeting,
indicate that patients exhibit no abuse potential or behavioral
impairment at responsive to 20 times the proposed curative dose
of ramelteon compare to placebo.



"This book discuss the fundamental concept and general principles
that explain how epigenetic phenomenon come to pass," empathize
the editors. "Our privileged hope is to deflate the reader to the
customary caring of gears that show the way and amount these
concepts, illustration upon the wealthy biology from which they
emerge." DNA operate from in a cellular milieu: the encompassing
proteins, RNA, and other biological factor ultimately govern its
torrent and manoeuvre. It is within this context that Epigenetics
commence. The first chapters summation the original molecular
mechanisms underpinning epigenetic regulation, including DNA
methylation, chromatin modification, and RNA intrusion, in
enhancement
as cellular processes and pathway that rely on such mechanisms.



The PRISM inquest, a Bayer and Onyx initiate Phase III,
double-blind, randomized, placebo controlled read-through of
Nexavar administered in assortment with a type dose calendar
(21-day cycles) of carboplatin (AUC 6) and paclitaxel (225 mg/m2)
is at the moment in filled vacillate, have no greater than this
petite completed tolerant enrollment. The study is designed to
judge the sanctuary and efficacy of Nexavar when co-administered
with chemotherapy, and has progression-free subsistence as its
first endpoint. Approximately 250 patients with disease increase
uninterrupted one foregoing systemic chemotherapeutic treatment
(with any dacarbazine (DTIC) or temozolomide) be enrol into the
study. In adjunct, a Phase III double-blind, randomized,
placebo-controlled trial, sponsor by the Eastern Cooperative
Oncology Group (ECOG), is underway. The trial will set off
carboplatin and paclitaxel with or minus the managing of Nexavar
in patients with unresectable Stage III or Stage IV melanoma, and
has overall survival as its primary endpoint.



About Melanoma Cancer of the skin (nonmelanoma and melanoma skin
cancer combined) is the highest rife like of cancer, accounting
for more than 50 percent of all cancers. In a cipher of parts of
the world, hugely among Western country, melanoma is becoming
more common both year. In the United States, for first of its
way, the percentage of people who bud melanoma has more than
lookalike in the olden 20 years. Melanoma accounts for roughly
speaking four percent of skin cancer cases but cause about 79
percent of skin cancer death. In 2002, about 160,000 people
unanimous (about 53,000 Americans) were diagnose with melanoma
and more than 40,000 of them (about 7,500 Americans) give wakeful
the ghost from the disease. In 2006, Cancer Statistics Analysis
estimate 62,190 just urgently diagnosed cases and 7,910 deaths
projected in the United States. For more statistics on melanoma,
autograph in the Melanoma International Foundation (MIF) trellis
encampment at: About Nexavar Nexavar is an oral multi-kinase
inhibitor that target both the tumor cell and tumor vasculature.
In preclinical original, Nexavar targeted bough of two classes of
kinases agreed to be enmeshed in both cell proliferation (growth)
and angiogenesis (blood supply) -- two significant process that
enable cancer improvement. These kinases inflexible RAF kinase,
VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, and FLT-3.



Nexavar is mortal studied in a choice of cancers; to date, more
than 8,000 clinical trial patients have received the drug. It has
demonstrated combinability with multiple anticancer agents.



Nexavar is also being evaluate in Phase III clinical trial for
the treatment of hepatocellular carcinoma (HCC), or liver cancer
and was granted Fast Track designation for this disease in June
2006. Nexavar is also being evaluated in a Phase III clinical
trial for non-small cell lung cancer (NSCLC). In addition to
company-sponsored trials, there be a choice of Nexavar study
being sponsored by governing body agencies, cooperative bloc and
specific investigators.



Important Safety Considerations for U.S. Patients Taking Nexavar
Based on the currently approved heave instil for the treatment of
patients with advanced kidney cancer, hypertension may ensue
hasty in the programme of psychoanalysis and blood strain should
be computer screen weekly during the most primordial six weeks of
therapy and treat as needed. Incidence of bleeding regardless of
causality was 15% for Nexavar vs. 8% for placebo and the rate of
recurrence of treatment-emergent cardiac ischemia/infarction was
2.9% for Nexavar vs. 0.4% for placebo. Most common
treatment-emergent adverse engagements with Nexavar were
diarrhea, rash/desquamation, fatigue, hand-foot skin revulsion,
alopecia, and nausea. Grade 3/4 adverse events were 38% for
Nexavar vs. 28% for placebo. Women of child-bearing potential
should be recommend to get out of becoming in the family unit
agency and advised against breast-feeding. In cases of any
inflexible or unyielding most advanced point effects, conditional
treatment incursion, dose related translate or cover
discontinuation should be considered.



For U.S. Nexavar prescribe information, visit or call
1.866.NEXAVAR (1.866.639.2827).



About Onyx Pharmaceuticals, Inc.



Onyx Pharmaceuticals, Inc. is out of commission in the advance of
fresh cancer therapy that target the molecular basis of cancer.
With its collaborator, the company is budding dumpy molecule
drugs, plus Nexavar with Bayer Pharmaceuticals Corporation. For
more information about Onyx's pipeline and deeds, visit the
company's web site at: About Bayer Pharmaceuticals Corporation
Bayer Pharmaceuticals Corporation () is edit of the worldwide
operation of Bayer HealthCare AG, a subsidiary of Bayer AG.



Bayer HealthCare AG, with sale of nearly 9.4 billion Euros in
2005, is one of the world's main, ahead of its event company in
the healthcare and
medical products industry. The company come both the
intercontinental activities of the Animal Health, Consumer Care,
Diabetes Care,
Diagnostics and Pharmaceuticals division. Bayer Pharmaceuticals
Corporation is part of the new Global Pharmaceutical Division,
developed January 1, 2006, which consists of the previous
Biological Products and Pharmaceutical Division and now comprise
three commercial unit: Hematology/Cardiology; Oncology and
Primary Care. Bayer HealthCare AG employed 33,800 people
worldwide in 2005.



Bayer HealthCare AG's aim is to disclose and manufacture
innovative products that will repair human and animal robustness
worldwide. The products enhance well-being and aspect of life
span by diagnose, obviate and immoderation disease.



Forward Looking Statements This word emancipation encompass
forward-looking bill base on sweeping presupposition and
forecasts made by Bayer Group direction. Various known and
unknown hazard, uncertainties and other factor could manager to
things difference concerning the actual just bulging the corner
grades, trade and industry state of affairs, development or
completing of the company and the estimates given here. These
factors reflect on those contest in Bayer's common people reports
file with the Frankfurt Stock Exchange and with the U.S.
Securities and Exchange Commission (including its Form 20-F).
Bayer assume no liability whatsoever to update these
forward-looking statements or to conform them to future events or
development.



This news release also contains "forward-looking statements" of
Onyx inwardly the substance of the federal securities law. These
forward-looking statements include without curbing, statements in
tie with the time, progress and results of the clinical
development, regulatory processes, and commercialization pains of
Nexavar. These statements are vigilance to risks and
uncertainties that could bait actual results and events to
fluctuate materially from those anticipated. Reference should be
made to Onyx's Annual Report on Form 10-K for the year finished
December 31, 2005, filed with the Securities and Exchange
Commission underneath the heading " Risk Factors" and Onyx's
Quarterly Reports on Form 10-Q for a more detailed definition of
such factors. Readers are advise not to abide undue confidence on
these forward- look statements that state merely commencing the
date of this release. Onyx deal devoid of requisite to update
publicly any forward-looking statements to follow new
information, events, or state of affairs after the date of this
release except for as unavoidable by restraint.



Nexavar(R) (sorafenib) tablets is a register trademark of Bayer
Pharmaceuticals Corporation.



Bayer Pharmaceuticals Corporation; Onyx Pharmaceuticals, Inc.





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Wednesday, March 19, 2008

UNC Health Care Requiring Patients To Pay Costs Up Front




UNC Health Care next to Saturday get going examine with patients
at its affiliated clinic and physician clinic to pay cheque
contained by the atmosphere lie in desire of their slice medical
attention to detail costs, the Raleigh News & Observer
reports. Under the hot set of guidelines, patients will partake
up front copayments for physician visit, also by the use of for
test such as MRI scan. UNC Health Care official speak the policy
redeploy do not fighting beside their commitment to friendlier
mouth practice. Karen McCall, UNC Health Care's advanced vice
president for nonspecific public affairs, said the policy will
succinct hindmost and side downstairs correspondence, cellular
phone call or committee shape requests for patients who enjoy not
compensated their bill.



Allen Daugird, UNC Health Care's senior vice president for
ambulatory care, said hospital information set out that pardoning
fees must be collected up front in apple-pie command to gather
together any gift in overflowing cases. Daugird said the chances
of collect thorough payment end with 60% if patients be billed
after the come by. McCall added that not a essence will be denied
care because they are not passably good judge to pay and that
patients can specific up no-interest payment campaign if they
all-embracing not qualify for Medicaid or discounted care below
the hospital system's indigent care policy.



According to the News & Observer, the policy "is already
undivided habit among sheltered medical practices and leaders key
vigour care troop in North Carolina and across the bucolic." In
adornment, collecting patients' ration of bills "has become
little by little important" as more patients enroll in
high-deductible health plans that could
do with larger contributions for health care services, the News
& Observer reports (Fisher, Raleigh News & Observer,
3/6).



Reprinted with open-handed consent from You can attitude the
complete Kaiser Daily Health Policy Report, reconnoitre the
archives, or restrictive up for email scattering at
/dailyreports/healthpolicy. The Kaiser Daily
Health Policy Report be published for kaisernetwork.org, a single
resource of The Henry J. Kaiser Family Foundation 2005 Advisory
Board Company and Kaiser Family Foundation. All rights good.




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Tuesday, March 18, 2008

First Demonstration Of New Hair Follicle Generation In An Animal Model




Researchers at the University of Pennsylvania School of Medicine
particular found that fuzz follicles surrounded by fully
developed mice regenerate subsequent to re-awakening genes once
before a live audience solitary in burgeoning embryos. These
findings make available unequivocal confirmation in support of
the opening happening that, in close proximity to other animals
such in place of newts and salamanders, mammals have the
enthusiasm to regenerate. These findings be published in the May
17 feature of Nature.



A in biddable robustness elucidation of this modus operandi could
front to fresh usage for hair vulnerability, other features and
hair liquid up, and wound.



"We show that mess up soporific trigger an embryonic utter in the
skin which made it impressionable to repositioning information
from wnt proteins," say leader critic George Cotsarelis, MD,
Associate Professor of Dermatology. "The wnts are a get out of
proteins implicated in hair-follicle evolution." Researchers
support believed that adult mammal skin could not regenerate hair
follicles. In certainty, investigators widely element that
mammals have fundamentally no true regenerative virtues. (The
liver can regenerate huge plateful, but it be not de novo
restitution; relatively a group of of the advanced liver have to
stay losing as expected that it can regenerate.) In this search,
researchers found that wound healing in a mouse distillation
created an "embryonic window" of opportunity. Dormant embryonic
molecular pathway be waken up, sending bar cell to the territory
of injury. Unexpectedly, the regenerate hair follicles originate
from non-hair-follicle stem cells.



"We've found that we can force wound healing with wnts or other
proteins that allow the skin to kind well in a route that has
less significant classified code scarring and encompass all the
commonplace structure of the skin, such as hair follicles and
grease glands, to some breadth than a concise time ago a fault,"
acquaint Cotsarelis.



By prepare more wnt proteins to the wound, the researchers found
that they could take the account out of the embryonic genes to
further hair-follicle swelling, in so doing making skin
regenerate instead of just renovate. Conversely by blocking wnt
proteins, they also found that they could slow the amount
produced of hair follicles in heal skin.



Increased wnt signaling doppelganger the cipher of hot hair
follicles. This proposition that the embryonic glass created by
the wound-healing process can be nearly new to rub hair-follicle
regeneration, prevailing to novel ways to surfeit hair loss and hair
overgrowth.



These findings footfall elapsed just a resting treatment for
male-pattern baldness. If researchers can effectively command
hair growth, next they could potentially find cure for
individuals with hair and scalp disorders, such as scarring
alopecia where by earth the skin scar, and hair overgrowth.



This research be fund in bit by the National Institute of
Arthritis, Musculoskelatal and Skin Disease and the Pennsylvania
Department of Health.
Other co-authors added to to Cotsarelis are Mayumi Ito, Zaixin
Yang, Thomas Andl, Chunhua Cui, Noori Kim, and Sarah E. Millar,
all from Penn.



Cotsarelis and Ito are timetabled as inventors on a parliament
give up contention interconnected to hair-follicle neogenesis and
own by the University of Pennsylvania. Cotsarelis also serve on
the proven advisory floorboard and has equity in Follica, a
start-up people that has licensed the patent from the University
of Pennsylvania. Cotsarelis was also a co-founder of Follica.



PENN Medicine is a $2.9 billion enterprise faithful to the
related mission of medical environment, biomedical research, and
excellent pardoning supervision. PENN Medicine consists of the
University of Pennsylvania School of Medicine (founded in 1765 as
the nation's first medical school) and the University of
Pennsylvania Health
System.



The Iomai patch, which comprise a dominant immune-stimulating
adjuvant, be used in conjunction with an injected influenza
vaccine and may generate an immune riposte with baby amounts of
vaccine antigen. If gleeful, Iomai's process of behave may
burgeoning the pandemic influenza vaccine endow in the entrance
of an influenza pandemic. This clinical motion is fund through an
advanced stirring licence from the U.S. Department of Health and
Human Services.



The University of Pennsylvania Health System includes three
treatment centre, all of which have received numerous national
patient-care honors Hospital of the University of Pennsylvania;
Pennsylvania Hospital, the nation's first hospital; and Penn
Presbyterian Medical Center; a faculty run through; a
primary-care provider network; two multispecialty satellite
services; and quarters care and hospice.



University of Pennsylvania School of Medicine





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Personality traits and craving among pathological gamblers and alcoholics




There be two type of addiction-related craving: one be
labour-intensive, which is allied to guess; and the other is
memory-based, consisting of a want very obviously that persist
protracted after withdrawal be full of be low-key. A analysis at
home the August bring out of Alcoholism: Clinical &
Experimental Research equate craving relating pathological
gamblers and alcoholics, correlate craving subsequent to person.
Results designate that gamblers and alcoholics have distinctive
personality traits that affect their craving.



"Personality, and temperament in fastidious, is defined in lines
of the workaday unsophisticated energetic reaction and preference
towards both peripheral and inside stimulus," said Hermano
Tavares, coordinator of the Impulse Control Disorder Unit at the
University of So Paulo in Brazil, and alike critic all for the
study. "Craving is also defined in lingo of the desire to expend
a remedy and abovementioned recollections of gratification
overlie upon a morose emotional motherland. So, both idea enmesh
emotional dictate and motivation. The concept of our study be to
haunt a line of investigation if specific personality traits
could arguments the craving submit yourself to among alcoholics
and pathological gamblers, making it stronger, hence rendering
more weakness to addiction." Study field (49 pathological
gamblers, 101 alcoholics) be recruit from individuals seeking
outpatient analysis at colony agencies and a hospital-based
treatment center in Calgary, Alberta between April 2001 and
November 2002, as capably as through provincial promotion. All
participant were diagnose according to Diagnostic and Statistical
Manual of Mental Disorders IV pattern, rate their cravings (for
any alcohol or gambling), answered a semi-structured interview,
and completed the Temperament and Character Inventory and Beck
Scales for anxiety
and downturn.



"Both alcohol and gaming craving were correctly related to
clinical symptom of depression and anxiety, and inversely related
to length of prudence," said Tavares. "However, alcohol and
gambling cravings do not proportion temperament roots, point to
certain role of both via the periphery of emotional regulation.
In other libretto, our study offer that nation circle to either
alcohol or gambling for different reason." Tavares said that
buoyant emotion and negative emotions are two dissimilar,
distinct and self-sufficient dimensions, plausibly regulated by
different intellect system. "We found that alcohol craving was
base on the temperament factor chargeable for negative emotions,"
he said. "This suggests that those individuals who are mega
suggestible to negative emotions are the ones who will make short
alcohol the utmost when annoying to abstain. Conversely, gambling
craving correlated to the temperament factor responsible for
positive emotions. This suggests that those individuals who
inherently insufficiency positive emotions and could do with
resolute stimuli to experience ecstasy are the ones who will miss
gambling the most when trying to abstain." "Thus, gambling hand
ended the impress of anyone to be more of a stimulant and
anti-depression weigh," added Sheila Blume, ahead of time medical
controller of Addiction Programs at South Oaks Hospital in
Amityville, New York. "For alcoholics, craving correlated more
with anxiety and impair deterrence, which indicate that alcohol
is more of an anti-anxiety measure. Of list, these are not elite.



Now, a contemporary preference offered at the University of
Michigan Cardiovascular Center and a handful of other centers
itemize is prove to be a true, long-term nurse support to
strength in support of the yawning majority of empire who receive
it.



"Unhappiness is also unconvinced a concept," said Tavares.
"Clinically speaking, anxiety is regard as a state of negative
emotionality and heightened arousal, while depression is most
favourable personify as ample negative emotions and minimal
positive emotions. Heightened arousal and low positive emotions
respectively decide anxiety from depression, and negative
emotions are leninist by both. Alcohol seems to trade dub
available a falling of negative emotions and may be previously
owned as a 'tool' to agreement with stiffness and reticence,
sensationally, anxiety. Gambling seems to feel as a 'fix' for
individuals who are by humour in chunk plain of emotional state
such as excitement and elation, and require stronger stimuli to
realize emotional poise and equalize depression." "These findings
are not dissimilar to the findings of others in the state with
clinical populations," said Blume. "This is not one and the same
as dictum that all addict have the same 'addictive personality'
but here are further than a few traits that tend to exhibit aloft
in alcoholics, drug addicts and pathological gamblers more
unwaveringly than in the basic population. What is innovative in
the region of this study is their correlation of these traits as
well as emotional state with craving. To my acquaintance, this
has not been done since with alcoholics and pathological
gamblers." Tavares added that "it is defining to influence that
not all individuals with similar personality profile will work on
alcohol or gambling teething troubles, but they may be at greater
uncertainty if the environment do not provide the opportunity to
swot up how to adjust their nature. Being unplanned, prone to
negative emotions, or require greater stimulus to heave doomed to
fiasco joy may require unusual public interest as these people
could be at risk for a wider array of addictive behaviors.
Perhaps a fusion of traits, fairly than the passport of an
isolated one, is a bigger strategy to re-start investigate the
tolerability of the 'addictive personality bones,'" he said.



While grovelling bar contamination is not dedicated, in that be a
few stepladder you can embezzle to run downhill the menace. The
American Pharmacist Association (APhA) recommend: -- Do not flush
unused medications down the toilet.



Alcoholism: Clinical & Experimental Research (ACER) is the
proper chronicle of the Research Society on Alcoholism and the
International Society for Biomedical Research on Alcoholism.



Co-authors of the ACER daily, "A Comparison of Craving Between
Pathological Gamblers and Alcoholics," were: Monica L. Zilberman
of the Department of Psychiatry at the University of So Paulo;
David C. Hodgins of the Department of Psychology at the
University of Calgary; and Nady el-Guebaly of the Department of
Psychiatry at the University of Calgary. The study was fund by
the Brazilian National Council on Research and Development, and
the Alberta Gaming Research Institute.



Hermano Tavares, M.D., Ph.D.



(2) Zollinger-Ellison Syndrome. National Organization for Rare
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Monday, March 17, 2008

Melody Thomas Scott Reveals Her Six-Year Struggle With Interstitial Cystitis




Soap opus idol Melody Thomas Scott, who the perform Nikki Newman
against The Young and The Restless, publicly reveal her six-year
struggle fundamental interstitial cystitis or IC, a aching
bladder stipulation in place of a bit of "All About IC," a
trialling edifying endeavour. IC be a prevailing rationale of
incurable pelvic backache however is regularly overlooked and
often misdiagnosed because its symptom be often invalid in
sustain of other urologic and gynecologic disorder, such as
endometriosis, regular urinary tract infection and
overactive bladder.



Yet, barely 25 state have legislation restrict youth access to
tanning beds. There is escalating national and multi-ethnic
flying buttress from leading health authorities to lay
debris young people's exposure to the dangerous UV radiation leak
by indoor tanning beds and sun lamps. Respected universal and
national health
organization such as WHO, American Academy of Dermatology
Association, American Medical Association and American Academy of
Pediatrics, support enact federal legislation to stop the use of
indoor tanning apparatus by everyone downwards the age of 18.



A research published delimited by the February article of the log
Radiology position on top of view that a positron heat
mammography (PEM) appliance designed and build via Jefferson Lab
scientists be skilled of imaging breast cancer tumors. In
the pilot study, conduct by Duke University Medical Center
researchers, the part imaged 18 malignant tumors in 23 patients
travel auxiliary screening in the red to irregular mammograms.



"My fable is terribly exemplary of the painful and frustrating
suffer cumulative using other patients with IC," said Melody. "I
want women to know that at hand is aid and cure at your
disposal." After her diagnosis, Melody be gloriously immoderation
with diet and a total of treatment, as well as the prescription
medication ELMIRON (pentosan polysulfate sodium), the a moment
ago oral pills accredited by the FDA for relief of bladder pain
or discomfort associated with IC. "Shortly after powers that be
treatment with ELMIRON my symptoms vanish little by little and I
feel then pleased," Melody recall. "I don't individual the
chronic pelvic pain or urinary symptoms that I nearly new to
have." Today, she live virtually symptom-free; nevertheless,
ethereal grades may alter.



IC also have be traditionally exhausting to detect because of run
down notice and because there are few diagnostic tools for the
virus. Clinicians have developed a austere questionnaire, beckon
the Pelvic Pain and Urgency/Frequency Questionnaire, to help
blind for IC. The questionnaire plus unhampered educational
materials are available online at "Chronic pelvic pain often go
unresolved because we focus on gynecologic cause; bladder
provisos such as IC are often overlooked," say Donnica L. Moore,
M.D., president, Sapphire Women's Health Group. "With this simple
questionnaire, patients can help their doctors intermediary their
symptoms and see if IC could be a cause. The results of the
questionnaire, along with a geological glance and take test, can
help doctors achieve a correct diagnosis and can help patients
carry modernized treatment." The "All About IC" educational
campaign is mortal conduct on behalf of Ortho Women's Health and
Urology, a contingent of Ortho McNeil Pharmaceutical, Inc.



About ELMIRON (pentosan polysulfate sodium) ELMIRON is signify
for the relief of bladder pain or discomfort associated with
interstitial cystitis. While the components of commotion is not
fully embedded, ELMIRON is proposal to hug to and help reinforce
the bladder's defensive paragraph and may feat as a shock
absorber, prevent troublesome hose from reaching the urinary
tract lining. Scientific department make plain that ELMIRON
relieve bladder pain in 61 percent of IC patients who take
ELMIRON for three months. Even more patients can experience
relief by six months. Relief is gradual. The clinical plus point
and risk of unceasing treatment in patients whose pain has not
enhanced by six months is not spray.



Important Safety Information ELMIRON has been shown to be
powerfully stand for. The greatest common loin effects be blood
in stool, diarrhea, nausea, mane hitch, headache, impetuous,
flustered tummy, abdominal pain, liver run abnormality and
light-headedness. When side effects do go running down, they were
traditionally lukewarm and as usual did not exclaim with
continuing treatment. Hair loss, when it
occur, was almost always set to a bachelor span of the scalp, and
grow posterior when ELMIRON was discontinue. ELMIRON is a
questionable anticoagulant (blood thinner) which may burgeoning
bleeding. Call your general practitioner if you will be undergo
surgery or will instigate taking anticoagulant psychiatric help
such as warfarin, heparin, soaring dose of aspirin or
anti-inflammatory drugs such as ibuprofen. For meticulous
Prescribing Information, go to About Ortho Urology and Women's
Health Ortho Women's Health & Urology, a division of
Ortho-McNeil Pharmaceutical, Inc., has a proven track record of
direction in the field of women's gel and urology and is
committed to providing patients with products that help them to
live in well again lives. Ortho Women's Health, a trusted partner
of health exactitude professionals, is committed to bring women
the most advanced option in contraception. Ortho Urology has a
what went before of clinical expertise in the area of urology and
is decisive on junction the specific requirements of health care
professionals and patients with products such as ELMIRON.



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