For Patients with Hypertension and Left Ventricular Hypertrophy, FDA Approves HYZAAR(reg) Part 3

If photograph blood nervous tension (<140/90 mmHg) be not make, hydrochlorothiazide (12.5 mg) was added original and, if needed, the dose of losartan or atenolol was after increased to 100 mg once daytime after day. If essential, other antihypertensive treatment (e.g., make better in dose of hydrochlorothiazide treatment to 25 mg or improvement of other diuretic therapy, calcium dwindling blockers, alpha-blockers, or centrally acting agents, but not ACE inhibitors, angiotensin II antagonists, or beta-blockers) be added to the glare of excitement regimen to reach the goal blood pressure.

Patients in the LIFE audible range were follow all for an mediocre of 4.8 years.

The grades show that in patients overload subsequent to losartan, the stake of first trend of cardiovascular annihilation, nonfatal soupcon or nonfatal myocardial infarction (primary endpoint) was reduced via a statistically chief 13 percent (p= 0.021) associate to patients treated with atenolol. This inequality was for the best chunk the outcome of an effect next to brutal and nonfatal stroke.

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The up and about to date gooey label for HYZAAR also identify that, in the LIFE trial, black patients with hypertension and LVH taking atenolol have a degrade risk of stroke than those taking COZAAR. Given the problem in interpret subset difference in colossal trial, it cannot be agreed whether the observed difference be the result of kismet. However, the LIFE hut make not offer authentication that the benefits of COZAAR on reducing the risk of cardiovascular trial in hypertensive patients with moved out ventricular hypertrophy apply to black patients.

The label indicate that the average starting dose for hypertensive patients with LVH is 50 mg of losartan once daily. Hydrochlorothiazide 12.5 mg should be added or HYZAAR 50-12.5 stand-in if the blood pressure decline is not enough. If superfluous blood pressure reduction is needed, COZAAR 100 mg and hydrochlorothiazide 12.5 mg may be substituted, followed by COZAAR 100 mg and hydrochlorothiazide 25 mg or HYZAAR 100-25. The maximum dose is one tablet of HYZAAR 100-25 once daily.

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