FOSRENOL(R) maintains bone health status of end-stage renal disease patients Part 4

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DESCRIPTION FOSRENOL(R) contain lanthanum carbonate (2:3) hydrate implicit molecular procedure La2(CO3)3 xH2O (on individual it in awareness x=4-5 mole of water) and molecular stowage 457.8 (anhydrous mass). Lanthanum (La) be a unsophisticatedly occurring special dust part. Lanthanum carbonate is practically insoluble delimited with hose.

Each FOSRENOL(R), white to off-white, chewable tablet contains lanthanum carbonate hydrate like to 250 or 500 mg of elemental lanthanum and the next motionless ingredient: dextrates (hydrated) NF, colloidal silicon dioxide NF, magnesium stearate NF, and talc USP.

Ocera Therapeutics, Inc., a privately-held biopharmaceutical guests bold higher than the fostering and commercialization of proprietary merged to extravagance gastrointestinal and liver illness announced today that it hold completed the tolerant enrollment of its Phase 3 exploration bordered through fistulizing Crohn's disease. This pivotal, double-blind, placebo controlled study, FHAST1 (Fistula Healing beside AST-120), has be designed to establish the efficacy and safekeeping of oral AST-120 in 240 patients with Crohn's disease hardship from perianal fistulas. Initial facts from the try-out will be reachable in the preliminary quarter of 2008.

Pharmacodynamics: Lanthanum carbonate dissociate in the sour environment of the upper GI tract to unlock lanthanum ions that lash dietary phosphate released from sustenance during digestion. FOSRENOL(R) inhibit absorption of phosphate by silhouette above all insoluble lanthanum phosphate obscure, hence reducing both serum phosphate and calcium phosphate product.

In vitro sanctum have shown that in the physiologically united pH inventory of 3 to 5 in gastric fluid, lanthanum bind roughly 97% of the unspoken for phosphate when lanthanum is in progress in a two-fold molar surfeit to phosphate. In lay down to bind dietary phosphate adroitly, lanthanum should be administered with or lacking hesitation after a teatime.

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